
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>CHARACTERIZATION OF A NOVEL TUMOR SUPPRESSOR BAX</dc:title>
  <dc:creator>Wang, Xin</dc:creator>
  <dc:description>Bax is a pro-death tumor suppressor. The loss of functional Bax expression can enhance the tumor growth. Recently we discovered a new family of functional Bax isoforms generated specifically in certain tumors; one of them is Bax 2 . In this thesis, I characterized the properties of Bax 2 protein by comparing with the parental Bax 2. Bax 2 was cloned into a GFP mammalian expression vector and transfected into the bax knockout cells. I examined Bax 2 expression, cellular distribution, and ability to induce cell death. The results show that the Bax 2 protein aggregated as granules around the nucleus in cytoplasm and induced more cell death than that from previously studied Bax 2. The results implicate that cancer patients with Bax 2 isoform might have better prognosis or response to treatment.</dc:description>
  <dc:description>M.S. in Biology, May 2013</dc:description>
  <dc:contributor>Xiang, Jialing</dc:contributor>
  <dc:date>2013-04-16</dc:date>
  <dc:date>2013-05</dc:date>
  <dc:type>Thesis</dc:type>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>islandora:9075</dc:identifier>
  <dc:identifier>http://hdl.handle.net/10560/3099</dc:identifier>
  <dc:source>BIOL / Biology</dc:source>
  <dc:source>Illinois Institute of Technology</dc:source>
  <dc:language>en</dc:language>
  <dc:rights>In Copyright</dc:rights>
  <dc:rights>http://rightsstatements.org/page/InC/1.0/</dc:rights>
  <dc:rights>Restricted Access</dc:rights>
</oai_dc:dc>