creator Han, Yujing advisor Guan, Xiyun Nanopore stochastic sensor using a biological protein ion channel has emerged as a powerful sensing technique due to its outstanding features such as label- and amplification-free detection, rapidness, high sensivity and selectivity. Development of a nanopore stochastic sensor for the rapid detection of anthrax can effectively prevent and control the spread of disease infection, and become extremely useful in biodefense. Two sensor design strategies were studied: one is chemistry-based detection of dipicolinic acid; and the other is genetics-based detection of anthrax lethal factor. Both approaches used in this study should find useful application in the development of nanopore sensors for the detection of other biomolecules and pathogens. Submitted by Liana Khananashvili (khananashvili@iit.edu) on 2014-10-20T18:59:30Z No. of bitstreams: 1 thesis.pdf: 1621057 bytes, checksum: 4b63483a21c9c0aca0cb10324057854b (MD5) Made available in DSpace on 2014-10-20T18:59:30Z (GMT). No. of bitstreams: 1 thesis.pdf: 1621057 bytes, checksum: 4b63483a21c9c0aca0cb10324057854b (MD5) Previous issue date: 2014-05 M.S. in Chemistry, May 2014 2014 2014-05 http://hdl.handle.net/10560/3284 en Thesis born digital application/pdf In Copyright http://rightsstatements.org/page/InC/1.0/ Restricted Access CHEM / Chemistry Illinois Institute of Technology Affiliated department