
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>NEUROPSYCHOLOGICAL PROFILES IN ADULTS WITH SICKLE CELL DISEASE</dc:title>
  <dc:creator>Piper, Lauren E.</dc:creator>
  <dc:description>Cognitive impairment is documented in individuals with sickle cell disease (SCD). Studies investigating cognitive impairment in this population have primarily examined group differences in neuropsychological performance, which may have overlooked the heterogeneity of cognitive functioning. The objectives of this study were to determine whether distinct cognitive profiles occur in individuals with SCD and, if so, to examine potential differences in demographic, clinical, and psychosocial characteristics. Participants with SCD (n = 73) and similarly matched controls (n = 82), completed a brief neuropsychological protocol (Hachinski et al., 2006) and self-report measures of pain and mood-related symptoms. Cluster analysis was used to identify groups of participants based on their cumulative scores across the domains of executive functioning, language, memory, and visuospatial ability. Multivariate analysis of variance (MANOVA) was used to compare the cluster groups across the four cognitive domains. Analysis of variance (ANOVA) and chi-square tests were used to compare cluster groups on demographic, clinical, and psychosocial characteristics. Results indicated three distinct cognitive subtypes: (1) executive and memory impaired (56% of participants); (2) globally impaired (14%); and (3) cognitively intact (30%). The three cluster groups did not differ on most demographic factors, stroke history, or pain severity, but differed on level of education and current mood-related distress. Results demonstrated the presence of distinct cognitive profiles in adults with SCD, with a proportion of cognitively intact individuals. Implications for intervention and cognitive rehabilitation are discussed.</dc:description>
  <dc:description>M.S. in Psychology, December 2014</dc:description>
  <dc:contributor>Lee, Eun-Jeong</dc:contributor>
  <dc:date>2014</dc:date>
  <dc:date>2014-12</dc:date>
  <dc:type>Thesis</dc:type>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>islandora:7388</dc:identifier>
  <dc:identifier>http://hdl.handle.net/10560/3444</dc:identifier>
  <dc:source>PSYCH / Institute of Psychology</dc:source>
  <dc:source>Illinois Institute of Technology</dc:source>
  <dc:language>en</dc:language>
  <dc:rights>In Copyright</dc:rights>
  <dc:rights>http://rightsstatements.org/page/InC/1.0/</dc:rights>
  <dc:rights>Restricted Access</dc:rights>
</oai_dc:dc>