
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Controlling biofilms using synthetic biology approaches</dc:title>
  <dc:subject>Biological Engineering</dc:subject>
  <dc:subject>Biotechnology</dc:subject>
  <dc:description>Bacterial biofilms are formed by the complex but ordered regulation of intra- or inter-cellular communication,
		environmentally responsive gene expression, and secretion of extracellular polymeric substances. Given the
		robust nature of bio?lms due to the non-growing nature of bio?lm bacteria and the physical barrier provided by
		the extracellular matrix, eradicating bio?lms is a very di?cult task to accomplish with conventional antibiotic
		or disinfectant treatments. Synthetic biology holds substantial promise for controlling bio?lms by improving and
		expanding existing biological tools, introducing novel functions to the system, and re-conceptualizing gene
		regulation. This review summarizes synthetic biology approaches used to eradicate bio?lms via protein
		engineering of bio?lm-related enzymes, utilization of synthetic genetic circuits, and the development of
		functional living agents. Synthetic biology also enables bene?cial applications of bio?lms through the
		production of biomaterials and patterning bio?lms with speci?c temporal and spatial structures. Advances in
		synthetic biology will add novel bio?lm functionalities for future therapeutic, biomanufacturing, and
		environmental applications.</dc:description>
  <dc:description>Sponsorship: NIH-R15AI130988, NSF CBET-1917130</dc:description>
  <dc:contributor>Fang, Kuili</dc:contributor>
  <dc:contributor>Park, Oh-Jin</dc:contributor>
  <dc:contributor>Hong, Seok Hoon</dc:contributor>
  <dc:date>2020</dc:date>
  <dc:type>Article</dc:type>
  <dc:identifier>islandora:1012025</dc:identifier>
  <dc:identifier>http://hdl.handle.net/10560/islandora:1012025</dc:identifier>
  <dc:source>ChBE / Chemical and Biological Engineering</dc:source>
  <dc:source>Illinois Institute of Technology</dc:source>
  <dc:language>en</dc:language>
  <dc:rights>Open Access</dc:rights>
</oai_dc:dc>