creator Yilmaz, Denizhan 2019 Spring 2019 Dissertation Illinois Institute of Technology ChBE / Chemical and Biological Engineering advisor Parulekar, Satish Bioengineering Antibody Production Cell Culture Fed-batch Kinetic Model en This dissertation proposes four different kinetic model frameworks that havebeen developed for optimization and control of monoclonal antibody producing mammalian cell cultures to improve biopharmaceutical production by decreasing the costof trial and error experimentation. The developed models mainly describe the transient metabolic behavior of mammalian cell culture under different culture conditionsand predicts cell growth and death, cell metabolism, and monoclonal antibody synthesis, and production. These models are developed via ordinary differential equationsbased on the assumption of well-mixing reactor. All developed models were calibrated, and their predictive capabilities were tested with experimental reports published in the literature. Good agreement was obtained between model predictions and experimental data. The presented results illustrate that the developed models successfully describe and predict the transient behavior of mammalian cell cultures and can be a useful tool for biopharmaceutical production. born digital application/pdf In Copyright http://rightsstatements.org/page/InC/1.0/ Restricted Access Embargo Until: 07/02/2020 http://hdl.handle.net/10560/islandora:1000866